Compound ID | 255

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Cytosporone B derivative

Class: Antivirulence agent

Agent Type: Semisynthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: Type III secretion system (T3SS) inhibitor
Target Pathogen: Active against Salmonella enterica serovar Typhimurium
Propensity to select resistant mutants: Yes
Description: Semisynthetic compound derived from the natural product fungal metabolite cytosporone B; shows no intrinsic antibacterial activity
Institute where first reported: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, China
Year first mentioned: 2010/2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 322.4
Iso. SMILES: CCCCCCCC(=O)C1=C(C=C(C=C1O)O)CC(=O)OCC
InChI Key: UVVWQQKSNZLUQA-UHFFFAOYSA-N
Can. SMILES: CCCCCCCC(=O)C1=C(C=C(C=C1O)O)CC(=O)OCC
InChI: InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10687292
Citation: http://aac.asm.org/content/57/5/2191.full

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