Compound ID | 2559

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Furanomycin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor (isoleucyl-tRNA synthetase [IleRS] inhibitor)
Target Pathogen: Active against Gram-positives, Shigella paradysenteriae, Salmonell paratyphi, and Escherichia coli
Description: Natural product from Streptomyces threomyceticus ATCC 15795 (also by Pseudomonas fluorescens)
Year first mentioned: 1998
Development status: Experimental
Chemical structure(s):
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Molecular weight: 157.17
Iso. SMILES: C[C@H]1C=C[C@@H](O1)[C@@H](C(=O)O)N
InChI Key: PNOKUGWGMLEAPE-JKUQZMGJSA-N
Can. SMILES: C[C@H]1C=C[C@H]([C@@H](C(=O)O)N)O1
InChI: InChI=1S/C7H11NO3/c1-4-2-3-5(11-4)6(8)7(9)10/h2-6H,8H2,1H3,(H,9,10)/t4-,5+,6-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/Furanomycin
Citations:
  • https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-13-111
  • https://pubs.acs.org/doi/epdf/10.1021/jm00318a035
  • https://pubs.rsc.org/en/content/articlepdf/1998/cc/a800727f

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