Compound ID | 2561

Update compound information

Gallidermin

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Active against Propionibacteria, Staphylococcus aureus, and Staphylococcus epidermidis
Description: Natural product from Staphylococcus gallinarum (F16/P57) Tü3928; differs to epidermidin by an exchange of Leu/Ile in position 6
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 2165.59
Iso. SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]1CSC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCCN)CC2=CC=CC=C2)CC(C)C)C(=O)N[C@@H]3[C@@H](SC[C@@H](NC(=O)CNC(=O)[C@@H]4CCCN4C3=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N/C(=C/C)/C(=O)NCC(=O)N[C@@H]5CSC[C@@H]6C(=O)N/C=C/SC[C@H](C(=O)N[C@H](C(=O)N6)CC7=CC=C(C=C7)O)NC(=O)[C@@H](NC(=O)[C@@H](NC5=O)CC8=CC=CC=C8)CC(=O)N)C)N
InChI Key: AHMZTHYNOXWCBS-PCUVAHMGSA-N
Can. SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]1CSC[C@H](C(=O)N[C@@H]2[C@H](C)SC[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N/C(=C/C)/C(=O)NCC(=O)N[C@@H]3CSC[C@@H]4C(=O)N/C=C/SC[C@H](C(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)N4)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC6=CC=CC=C6)NC3=O)NC(=O)CNC(=O)[C@@H]7CCCN7C2=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H](CCCCN)NC1=O)N
InChI: InChI=1S/C98H141N25O23S4/c1-9-52(5)78(102)97(145)107-54(7)81(129)118-71-48-149-49-72(121-86(134)63(38-51(3)4)113-87(135)64(39-56-22-13-11-14-23-56)114-85(133)62(112-93(71)141)27-18-20-34-100)95(143)122-79-55(8)150-50-73(109-77(127)44-105-96(144)74-28-21-36-123(74)98(79)146)91(139)106-53(6)80(128)111-61(26-17-19-33-99)84(132)110-60(10-2)82(130)104-43-76(126)108-69-47-148-46-68-83(131)103-35-37-147-45-70(94(142)116-66(89(137)119-68)41-58-29-31-59(124)32-30-58)120-90(138)67(42-75(101)125)117-88(136)65(115-92(69)140)40-57-24-15-12-16-25-57/h10-16,22-25,29-32,35,37,51-55,61-74,78-79,124H,9,17-21,26-28,33-34,36,38-50,99-100,102H2,1-8H3,(H2,101,125)(H,103,131)(H,104,130)(H,105,144)(H,106,139)(H,107,145)(H,108,126)(H,109,127)(H,110,132)(H,111,128)(H,112,141)(H,113,135)(H,114,133)(H,115,140)(H,116,142)(H,117,136)(H,118,129)(H,119,137)(H,120,138)(H,121,134)(H,122,143)/b37-35+,60-10+/t52-,53-,54-,55-,61-,62-,63-,64-,65-,66-,67-,68+,69+,70+,71+,72+,73+,74-,78-,79+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/73348284
Citations:
  • https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1988.tb14344.x-i2?sid=nlm%3Apubmed
  • https://onlinelibrary.wiley.com/doi/epdf/10.1002/mbo3.606

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