Compound ID | 2569

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Hikizimycin

Synonym(s): Anthelmycin

Class: Nucleoside analogue

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Pseudomonas sp.
Description: Natural product from Streptomyces sp. A-5 (also by Streptomyces longissimus); has antihelminthic activity
Year first mentioned: 1979
Development status: Experimental
Chemical structure(s):
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Molecular weight: 583.54
Iso. SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)[C@@H]([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N)O)O
InChI Key: VQQSDVBOXQHCHU-SKPOXZENSA-N
Can. SMILES: C1=CN([C@H]2[C@@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)N)O)O2)N)O)O)C(=O)N=C1N
InChI: InChI=1S/C21H37N5O14/c22-7-1-2-26(21(37)25-7)19-16(36)12(32)9(24)17(39-19)18(15(35)14(34)10(30)5(29)3-27)40-20-13(33)8(23)11(31)6(4-28)38-20/h1-2,5-6,8-20,27-36H,3-4,23-24H2,(H2,22,25,37)/t5-,6-,8+,9+,10-,11-,12+,13-,14+,15+,16-,17+,18-,19-,20+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/75905628
Citations:
  • https://www.sciencedirect.com/science/article/pii/0005278779901485?via%3Dihub
  • https://pubs.acs.org/doi/10.1021/acs.joc.1c01773

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