Compound ID | 257

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SRI-20920

Class: Folate synthesis inhibitor

Agent Type: Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Folate synthesis inhibitor. Dihydrofolate reductase inhibitor
Target Pathogen: Active against Mycobacterium avium and Mycobacterium tuberculosis
Description: Barrow EW, Suling WJ, Seitz, LE, etc. Screening of new selective inhibitors for Mycobacterium avium DHFR. Poster F-734 44th-ICAAC 2004;206.
Institute where first reported: Oklahoma State Univ., Coll of Vet. Med., US; Southern Res. Inst., USA
Year first mentioned: 2004
Development status: Experimental
Reason dropped: These were presented in early stages of the work. They suggest other compounds in the series in development which better solubility and selectivity, it is likely, these were superseded.
Chemical structure(s):
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Molecular weight: 382.46
Iso. SMILES: CCCOC1=C(C=C(C=C1)OCC)NCC2=CN=C3C(=C2C)C(=NC(=N3)N)N
InChI Key: SZAZJRVSIHGLCG-UHFFFAOYSA-N
Can. SMILES: CCCOC1=CC=C(C=C1NCC2=C(C)C3=C(N)N=C(N)N=C3N=C2)OCC
InChI: InChI=1S/C20H26N6O2/c1-4-8-28-16-7-6-14(27-5-2)9-15(16)23-10-13-11-24-19-17(12(13)3)18(21)25-20(22)26-19/h6-7,9,11,23H,4-5,8,10H2,1-3H3,(H4,21,22,24,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/15954345
Guide to Pharmacology: SRI-20920
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280141/

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