Compound ID | 2576

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Juglomycin

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Escherichia coli, Shigella dysenteriae, Pseudomonas fluorescens, methicillin-resistant and -susceptible Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus warneri, and Clostridium pasteurianum; likely inhibits protein synthesis
Description: Natural product from Streptomyces achromogenes E91CS4 (also by Streptomyces sp. 190‐2, S. diastatochromogens, and S. tendae Tii 9015); synergistic effect with streptomycin; a naphthoquinone
Year first mentioned: 1971
Development status: Experimental
Chemical structure(s):
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Molecular weight: 290.27
Iso. SMILES: CC1=C(C(=O)C2=C(C1=O)C(=CC=C2)O)C[C@@H](CC(=O)O)O
InChI Key: MIJQQLCPVSCPSU-QMMMGPOBSA-N
Can. SMILES: CC1=C(C[C@@H](CC(=O)O)O)C(=O)C2=CC=CC(=C2C1=O)O
InChI: InChI=1S/C15H14O6/c1-7-10(5-8(16)6-12(18)19)15(21)9-3-2-4-11(17)13(9)14(7)20/h2-4,8,16-17H,5-6H2,1H3,(H,18,19)/t8-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/190948
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/47/10/47_10_1116/_article
  • https://academic.oup.com/jambio/article/128/5/1366/6715073?login=true

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