Compound ID | 2596

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Lividomycin A

Synonym(s): Lividomycin

Class: Aminoglycoside

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Pseudomonas aeruginosa, Staphylococcus aureus, Corynebacterium diphtheriae, Salmonella typhosa, Salmonella paratyphi, Klebsiella pneumoniae, Shigella sp. and Mycobacterium tuberculosis
Description: Natural product from Streptomyces lividus; lividomycin-resistant S. aureus are also resistant to kanamycin, streptomycin, and gentamicin
Year first mentioned: 1972
Development status: Experimental
Chemical structure(s):
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Molecular weight: 761.77
Iso. SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H](C[C@@H]([C@H](O2)CO)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O[C@@H]5[C@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)N)O)O)N
InChI Key: DBLVDAUGBTYDFR-SWMBIRFSSA-N
Can. SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H](C[C@@H]([C@@H](CO)O2)O)N)O[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](CN)O4)O[C@@H]5[C@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)O)N)O)O)N
InChI: InChI=1S/C29H55N5O18/c30-3-11-23(51-28-20(43)19(42)17(40)13(5-36)47-28)18(41)15(34)27(45-11)50-24-14(6-37)48-29(21(24)44)52-25-16(39)7(31)1-8(32)22(25)49-26-9(33)2-10(38)12(4-35)46-26/h7-29,35-44H,1-6,30-34H2/t7-,8+,9-,10+,11+,12-,13-,14-,15-,16+,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/72394
Citations:
  • https://journals.asm.org/doi/10.1128/aac.1.1.17?doi=10.1128/aac.1.1.17
  • https://www.jstage.jst.go.jp/article/antibiotics1968/25/2/25_2_128/_article

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