Balofloxacin

Synonym(s): Q-35

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	For use against urinary (approved) and respiratory tract infections; inhibits DNA gyrase and topoisomerase IV enzymes
Description:	Synthetic compound; a fourth generation fluoroquinolone
Institute where first reported:	Choongwae Pharma (Korea)
Year first mentioned:	2005
Highest developmental phase:	Phase 3 (Korea)
Development status:	Approved in Korea

Chemical structure(s):
Canonical SMILES:	CNC1CCCN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC
Isomeric SMILES:	CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI:	InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
InChI Key:	MGQLHRYJBWGORO-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/65958

External links:
Guide to Pharmacology:	balofloxacin
Main Source:	https://www.sciencedirect.com/science/article/pii/S0731708518313025