Compound ID | 2603

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Balofloxacin

Synonym(s): Q-35

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Inhibits DNA gyrase and topoisomerase IV enzymes
Target Pathogen: For use against urinary (approved) and respiratory tract infections
Description: Synthetic compound; a fourth generation fluoroquinolone
Institute where first reported: Choongwae Pharma (Korea)
Year first mentioned: 2005
Highest developmental phase: Approved in Korea
Development status: Approved
Chemical structure(s):
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Molecular weight: 389.42
Iso. SMILES: CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI Key: MGQLHRYJBWGORO-UHFFFAOYSA-N
Can. SMILES: CNC1CCCN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC
InChI: InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/65958
Guide to Pharmacology: balofloxacin
Citation: https://www.sciencedirect.com/science/article/pii/S0731708518313025

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