Compound ID | 2604
AGXX
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Small molecule; Direct acting; Antibiotic adjuvant; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Induces production of reactive oxygen species which damage cellular macromolecules; also increases inner and outer permeability facilitating uptake of aminoglycosides in Pseudomonas aeruginosa |
| Target Pathogen: | Active against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa; |
| Description: | Synthetic compound consisting of silver and ruthenium; shows antibacterial activity on its own but also potentiates aminoglycosides |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/msphere.00190-23 |
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