Compound ID | 2608

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Megovalicin D, megovalicin G, megovalicin H

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Pseudomonas aeruginosa (only megovalicin H) and Escherichia coli
Description: Natural product from Myxococcus flavescens
Institute where first reported: Central Research Laboratories, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki 210, Kanagawa, Japan
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
Megovalicin H
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Molecular weight: 609.88
Iso. SMILES: CCC[C@H]1C(=O)NC[C@@H](C[C@@H]([C@@H](CC/C(=C/C=C[C@H](CCCCCCCC[C@@H](C[C@H](C(=O)O1)C)C)CC)/COC)O)O)O
InChI Key: VLCIAVLHXXOWFZ-DOQXKKBUSA-N
Can. SMILES: CCC[C@H]1C(=O)NC[C@@H](C[C@@H]([C@@H](CC/C(=C/C=C[C@@H](CC)CCCCCCCC[C@H](C)C[C@@H](C)C(=O)O1)/COC)O)O)O
InChI: InChI=1S/C35H63NO7/c1-6-15-33-34(40)36-24-30(37)23-32(39)31(38)21-20-29(25-42-5)19-14-18-28(7-2)17-13-11-9-8-10-12-16-26(3)22-27(4)35(41)43-33/h14,18-19,26-28,30-33,37-39H,6-13,15-17,20-25H2,1-5H3,(H,36,40)/b18-14?,29-19-/t26-,27+,28-,30+,31+,32-,33-/m0/s1
Megovalicin G
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Molecular weight: 607.86
Iso. SMILES: CCC[C@H]1C(=O)NC[C@H](C[C@@H]([C@@H](CC/C(=C/C=C/C(CCCCCCCC[C@H](/C=C(/C(=O)O1)\C)C)CC)/COC)O)O)O
InChI Key: KPPGZMXMBMURID-UVLJCXNLSA-N
Can. SMILES: CCC[C@H]1C(=O)NC[C@H](C[C@@H]([C@@H](CC/C(=C/C=C/C(CC)CCCCCCCC[C@@H](C)/C=C(\C)/C(=O)O1)/COC)O)O)O
InChI: InChI=1S/C35H61NO7/c1-6-15-33-34(40)36-24-30(37)23-32(39)31(38)21-20-29(25-42-5)19-14-18-28(7-2)17-13-11-9-8-10-12-16-26(3)22-27(4)35(41)43-33/h14,18-19,22,26,28,30-33,37-39H,6-13,15-17,20-21,23-25H2,1-5H3,(H,36,40)/b18-14+,27-22+,29-19-/t26-,28?,30+,31-,32+,33+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11758398
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/163184494
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/41/4/41_4_433/_pdf/-char/en

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