Compound ID | 261
OPT-382
Class: Aminoglycoside
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Activity is similar to amikacin against Pseudomonas aeruginosa but in the mouse model has significantly reduced acute toxicity |
| Description: | Sucheck SJ, Yao S, Sgarbi PWM, et al. Discovery of novel aminoglycosides through OPopS glycosylation. 43rd-ICAAC 2003;272 |
| Institute where first reported: | Optimer Pharmaceuticals, Singapore |
| Year first mentioned: | 2003 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | Was from the same program as fidaxomycin where 4 lead products were identified, with the exception of fidaxomycin, everything was discontinued. |
| External links: | |
| Citation: |
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