Mepicycline

Synonym(s): Pipacycline

Class: Tetracycline

Spectrum of activity:	Gram-positive
Details of activity:	Active against penicillinase-producing Staphylococcus aureus; protein synthesis inhibitor
Combined with other compounds:	Yes, part of penimepicycline
Description:	Semi-synthetic compound derived from tetracycline; component of the penicillinate salt penimepicycline (used in combination with phenoxymethylpenicillin)
Institute where first reported:	Farmaceutici Midy Research Laboratories – Milano
Year first mentioned:	1962
Development status:	Unknown

Chemical structure(s):
Canonical SMILES:	C[C@]1(C2=CC=CC(=C2C(=C3[C@@H]1C[C@H]4[C@@H](C(=O)C(=C([C@]4(C3=O)O)O)C(=O)NCN5CCN(CC5)CCO)N(C)C)O)O)O
Isomeric SMILES:	C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCN5CCN(CC5)CCO)N(C)C)O
InChI:	InChI=1S/C29H38N4O9/c1-28(41)15-5-4-6-18(35)19(15)23(36)20-16(28)13-17-22(31(2)3)24(37)21(26(39)29(17,42)25(20)38)27(40)30-14-33-9-7-32(8-10-33)11-12-34/h4-6,16-17,22,34-36,39,41-42H,7-14H2,1-3H3,(H,30,40)/t16-,17-,22-,28+,29-/m0/s1
InChI Key:	RAUQZDNDLCIQFJ-REHNUXHNSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/54686184

External links:
Guide to Pharmacology:	pipacycline
Main Source:	https://karger.com/cth/article/5/3-4/242/90094/Mepicycline-a-New-Soluble-Tetracycline-Derivative
Patent:	BE709002A