Compound ID | 2612

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Sch 33256

Synonym(s): 2'-N-methyl-8-methoxychlortetracycline

Class: Tetracycline

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus and Streptococcus sp.; protein synthesis inhibitor
Description: Natural product from Actinomadura brunnea; derivative of chlortetracycline
Institute where first reported: Department of Microbial Products, Schering Corporation (NJ, USA)
Year first mentioned: 1987
Development status: Unknown
Chemical structure(s):
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Molecular weight: 522.93
Iso. SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C(=C(C=C4O)OC)Cl)O)O)O)C(=O)NC)N(C)C)O
InChI Key: WQGJHOQATLCJIW-SBAZJYRFSA-N
Can. SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C(=C(C=C4O)OC)Cl)O)O)O)C(=O)NC)N(C)C)O
InChI: InChI=1S/C24H27ClN2O9/c1-23(34)8-6-9-17(27(3)4)19(30)14(22(33)26-2)21(32)24(9,35)20(31)12(8)18(29)13-10(28)7-11(36-5)16(25)15(13)23/h7-9,17,28-29,32,34-35H,6H2,1-5H3,(H,26,33)/t8-,9-,17-,23-,24-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54693039
Citations:
  • https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt196233284
  • https://www.jstage.jst.go.jp/article/antibiotics1968/40/10/40_10_1426/_pdf/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/40/10/40_10_1408/_pdf/-char/en

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