Compound ID | 2613

Update compound information

8-Methoxychlortetracycline

Synonym(s): 8-methoxychlorotetracycline  |  Sch 36969

Class: Tetracycline

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against tetracycline-resistant and -susceptible Gram-negatives and methicillin-resistant and -susceptible Gram-positives
Description: Natural product from a mutant (blocked 2'-amino position methylation) Actinomadura brunnea; shows the same efficacy in vivo (mice) as tetracycline
Institute where first reported: Schering Corporation NJ USA
Year first mentioned: 1987
Development status: Unknown
Chemical structure(s):
Click here for structure editor
Molecular weight: 508.91
Iso. SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C(=C(C=C4O)OC)Cl)O)O)O)C(=O)N)N(C)C)O
InChI Key: LITNLJPOCNTUJW-QYPDEEGYSA-N
Can. SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C(=C(C=C4O)OC)Cl)O)O)O)C(=O)N)N(C)C)O
InChI: InChI=1S/C23H25ClN2O9/c1-22(33)7-5-8-16(26(2)3)18(29)13(21(25)32)20(31)23(8,34)19(30)11(7)17(28)12-9(27)6-10(35-4)15(24)14(12)22/h6-8,16,27-28,31,33-34H,5H2,1-4H3,(H2,25,32)/t7-,8-,16-,22-,23-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54692978
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/40/10/40_10_1426/_pdf/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/40/10/40_10_1419/_article

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.