Pikromycin

Synonym(s): Albomycetin  |  amaromycin

Class: Macrolide (ketolide)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Broad-spectrum activity; targets protein synthesis by binding to overlapping sites in the ribosomal exit tunnel however it only inhibits a limited number of proteins
Description:	Natural product from Streptomyces venezuelae
Year first mentioned:	1968
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC[C@@H]1[C@](C)(/C=C/C(=O)[C@H](C)C[C@H](C)[C@@H]([C@@H](C)C(=O)[C@@H](C)C(=O)O1)O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)O
Isomeric SMILES:	CC[C@@H]1[C@@](/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]2[C@@H]([C@H](C[C@H](O2)C)N(C)C)O)C)C)(C)O
InChI:	InChI=1S/C28H47NO8/c1-10-22-28(7,34)12-11-21(30)15(2)13-16(3)25(18(5)23(31)19(6)26(33)36-22)37-27-24(32)20(29(8)9)14-17(4)35-27/h11-12,15-20,22,24-25,27,32,34H,10,13-14H2,1-9H3/b12-11+/t15-,16+,17-,18+,19-,20+,22-,24-,25+,27+,28+/m1/s1
InChI Key:	UZQBOFAUUTZOQE-VSLWXVDYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5282037

External links:
Guide to Pharmacology:	pikromycin
Main Source:	https://academic.oup.com/nar/article/45/16/9573/4056244?login=true#108560249
Citation:	https://pubs.acs.org/doi/abs/10.1021/ja01019a055
Patent:	WO2000000620A3