Compound ID | 2631

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Mutalomycin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus, Streptococcus faecalis, and Clostridium pasteurianum (also shows anticoccidial activity)
Description: Natural product from Streptomyces mutabilis; metal-complexing polyether antibiotic; structurally related to nigericin
Institute where first reported: Sandoz Ltd., Pharmaceutical Division, Chemical Research CH-4002 Basle, Switzerland
Year first mentioned: 1977
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 754.99
Iso. SMILES: C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@H](O2)[C@@]3(CC[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@@H]6[C@@H]([C@@H]([C@H]([C@@](O6)([C@H](C)C(=O)O)O)C)OC)C)C)O)C)C)C)(C)O)C
InChI Key: WWEDNBWYGGJQOV-RIWLGXEFSA-N
Can. SMILES: C[C@H]1C[C@@H](C)[C@@](C)(O)O[C@@H]1[C@H]2C[C@H](C)[C@H]([C@]3(C)CC[C@H]([C@]4(C)CC[C@]5(C[C@@H]([C@@H](C)[C@@H]([C@@H](C)[C@@H]6[C@H](C)[C@@H]([C@@H](C)[C@@]([C@H](C)C(=O)O)(O)O6)OC)O5)O)O4)O3)O2
InChI: InChI=1S/C41H70O12/c1-20-17-22(3)39(11,45)50-31(20)29-18-21(2)35(48-29)38(10)14-13-30(49-38)37(9)15-16-40(53-37)19-28(42)23(4)32(51-40)24(5)33-25(6)34(47-12)26(7)41(46,52-33)27(8)36(43)44/h20-35,42,45-46H,13-19H2,1-12H3,(H,43,44)/t20-,21-,22+,23+,24+,25-,26+,27+,28-,29+,30+,31-,32-,33+,34-,35+,37-,38-,39-,40+,41+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/86289410
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/9/33_9_979/_pdf/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/30/11/30_11_903/_pdf/-char/en

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