Compound ID | 2634

Update compound information

Mycinamicin

Class: Macrolide

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Corynebacterium diphtheriae
Description: Natural product from Micromonospora griseorubida; synthetic analogues reported elsewhere
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 711.88
Iso. SMILES: CC[C@@H]1[C@H](C2C(O2)/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](/C=C/C(=O)O1)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)C)C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC
InChI Key: QABCJBNUVVMWAL-HXRJSAKRSA-N
Can. SMILES: CC[C@@H]1[C@@H](CO[C@H]2[C@@H]([C@@H]([C@@H]([C@@H](C)O2)O)OC)OC)C3C(/C=C/C(=O)[C@H](C)C[C@H](C)[C@@H]([C@@H](C)/C=C/C(=O)O1)O[C@H]4[C@@H]([C@H](C[C@@H](C)O4)N(C)C)O)O3
InChI: InChI=1S/C37H61NO12/c1-11-27-24(18-45-37-35(44-10)34(43-9)30(41)23(6)47-37)33-28(49-33)14-13-26(39)20(3)16-21(4)32(19(2)12-15-29(40)48-27)50-36-31(42)25(38(7)8)17-22(5)46-36/h12-15,19-25,27-28,30-37,41-42H,11,16-18H2,1-10H3/b14-13+,15-12+/t19-,20+,21-,22+,23+,24+,25-,27+,28?,30+,31+,32+,33?,34+,35+,36-,37+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6447308
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/4/33_4_364/_pdf/-char/en
  • https://academic.oup.com/nar/article/49/16/9560/6355883

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