Compound ID | 2648

Update compound information

Nocardamin

Synonym(s): Deferriferrioxamine E  |  nocardamine

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Chelates iron; also inhibits the tetracycline efflux pump
Description: Natural product from Nocardia sp. (and also by Streptomyces avermitilis, Chromobacterium sp., and Pseudomonas sp.); a siderophore
Year first mentioned: 1982
Development status: Experimental
Chemical structure(s):
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Molecular weight: 600.71
Iso. SMILES: C1CCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CC1)O)O)O
InChI Key: NHKCCADZVLTPPO-UHFFFAOYSA-N
Can. SMILES: C1CCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CC1)O)O)O
InChI: InChI=1S/C27H48N6O9/c34-22-10-14-26(38)32(41)20-8-3-6-18-30-24(36)12-15-27(39)33(42)21-9-2-5-17-29-23(35)11-13-25(37)31(40)19-7-1-4-16-28-22/h40-42H,1-21H2,(H,28,34)(H,29,35)(H,30,36)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/161532
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188031/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC216636/pdf/jbacter00260-0399.pdf
  • https://web.archive.org/web/20170716180711id_/https://www.jstage.jst.go.jp/article/saj/23/2/23_SAJ230203/_pdf

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