IT-62-B

Class: Anthracycline

Spectrum of activity:	Gram-positive
Details of activity:	Cytostatic antibiotic which acts by inhibiting signal transduction pathways involving rasp21. Demonstrates antitumor and antibacterial activity- Gram positive but not Gram negative except for E. coli
Institute where first reported:	Taisho Pharmaceuticals, Japan
Year first mentioned:	1995
Highest developmental phase:	Preclinical
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CC(CO)C1C(=O)N2[C@H]3CC(O[C@@H](C)[C@H]3OC(CC(C)O)OC(C)C2O1)O[C@H]4C[C@@](CC5=C(C6=C(C(=O)C7=C(C=CC=C7C6=O)OC)C(=C54)O)O)(C(=O)C)O
Isomeric SMILES:	C[C@H]1[C@@H]2[C@H](CC(O1)O[C@H]3C[C@@](CC4=C3C(=C5C(=C4O)C(=O)C6=C(C5=O)C(=CC=C6)OC)O)(C(=O)C)O)N7C(C(OC(O2)CC(C)O)C)OC(C7=O)C(C)CO
InChI:	InChI=1S/C39H47NO15/c1-15(14-41)35-37(48)40-22-11-26(51-17(3)36(22)54-25(10-16(2)42)52-18(4)38(40)55-35)53-24-13-39(49,19(5)43)12-21-28(24)34(47)30-29(32(21)45)31(44)20-8-7-9-23(50-6)27(20)33(30)46/h7-9,15-18,22,24-26,35-36,38,41-42,45,47,49H,10-14H2,1-6H3/t15?,16?,17-,18?,22-,24-,25?,26?,35?,36+,38?,39-/m0/s1
InChI Key:	JVRLFIBJALHFAP-JLHPLHHJSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/139584829

External links:
Guide to Pharmacology:	IT-62-B
Main Source:	https://www.jstage.jst.go.jp/article/antibiotics1968/50/4/50_4_297/_pdf/-char/en
Citation:	https://www.jstage.jst.go.jp/article/antibiotics1968/50/4/50_4_297/_article