Compound ID | 2651

Update compound information

Novenamine

Synonym(s): U-33,918

Class: Aminocoumarin

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas fluorescens
Description: Semisynthetic derivative of novobiocin; prepared from enzymatic cleavage by Arthrobacter sp. during anaerobic conditions
Institute where first reported: The Upjohn Company, Kalamazoo, Michigan USA
Year first mentioned: 1972
Development status: Experimental
Chemical structure(s):
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Molecular weight: 424.4
Iso. SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)N)O[C@H]3[C@@H]([C@@H]([C@H](C(O3)(C)C)OC)OC(=O)N)O
InChI Key: RXMJJPBQGFPXEP-DUFGSWQCSA-N
Can. SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)N)O[C@H]3[C@@H]([C@@H]([C@H](C(C)(C)O3)OC)OC(=O)N)O
InChI: InChI=1S/C19H24N2O9/c1-7-9(6-5-8-11(22)10(20)16(24)28-13(7)8)27-17-12(23)14(29-18(21)25)15(26-4)19(2,3)30-17/h5-6,12,14-15,17,22-23H,20H2,1-4H3,(H2,21,25)/t12-,14+,15-,17-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54682465
Citations:
  • https://www.sciencedirect.com/science/article/pii/0006295296000615?via%3Dihub
  • https://www.jstage.jst.go.jp/article/antibiotics1968/25/7/25_7_434/_pdf/-char/en
    • Patent: US3652536A

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