Compound ID | 2652

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Nybomycin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: DNA synthesis inhibitor. Bacterial topoisomerase inhibitor (anthracycline)
Target Pathogen: Active against Staphylococcus aureus, Klebsiella pneumoniae, and Mycobacterium smegmatis
Description: Natural product from Streptomyces A-717
Year first mentioned: 1955
Development status: Experimental
Chemical structure(s):
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Molecular weight: 298.29
Iso. SMILES: CC1=CC(=O)N2COC3=C2C1=CC4=C3N(C(=O)C=C4CO)C
InChI Key: HKMUGCUFXWTNSP-UHFFFAOYSA-N
Can. SMILES: CC1=CC(=O)N2COC3=C4C(=CC1=C32)C(=CC(=O)N4C)CO
InChI: InChI=1S/C16H14N2O4/c1-8-3-13(21)18-7-22-16-14-11(5-10(8)15(16)18)9(6-19)4-12(20)17(14)2/h3-5,19H,6-7H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/169159
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/33593838/#:~:text=An%20attractive%20class%20of%20compounds,strains%20with%20FQ%2Dsensitive%20gyrases.
  • https://www.sciencedirect.com/science/article/pii/S1096717623001775
  • https://www.pnas.org/doi/10.1073/pnas.41.9.620

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