Compound ID | 2656

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Pactamycin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Broad-spectrum activity
Description: Natural product from Streptomyces pactum; also shows anti-tumour properties
Institute where first reported: Department of Biochemistry, Upjohn Company, Kalamazoo, Mich., U.S.A.
Year first mentioned: 1962
Development status: Experimental
Chemical structure(s):
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Molecular weight: 558.62
Iso. SMILES: CC1=C(C(=CC=C1)O)C(=O)OC[C@]2([C@H]([C@@H]([C@]([C@@]2(C)O)([C@H](C)O)NC(=O)N(C)C)N)NC3=CC=CC(=C3)C(=O)C)O
InChI Key: WVIUOSJLUCTGFK-JUJPXXQGSA-N
Can. SMILES: CC1=CC=CC(=C1C(=O)OC[C@]2([C@H]([C@@H]([C@@]([C@H](C)O)([C@@]2(C)O)NC(=O)N(C)C)N)NC3=CC(=CC=C3)C(=O)C)O)O
InChI: InChI=1S/C28H38N4O8/c1-15-9-7-12-20(35)21(15)24(36)40-14-27(39)23(30-19-11-8-10-18(13-19)16(2)33)22(29)28(17(3)34,26(27,4)38)31-25(37)32(5)6/h7-13,17,22-23,30,34-35,38-39H,14,29H2,1-6H3,(H,31,37)/t17-,22-,23-,26-,27+,28-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5289124
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1057863/pdf/applmicro00342-0024.pdf
  • https://pdf.sciencedirectassets.com/271311/1-s2.0-S0006295200X07204/1-s2.0-0006295267901165/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEIL%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIDN%2B0XsJrHP1JwHK6XaNfTA4ZTBywX%2Fkk6jXea90ntG4AiBoGLBeKGGXPb5loTPgJ7k%2FZWr4lgm9KyQ%2BOim13xYqwSqyBQgrEAUaDDA1OTAwMzU0Njg2NSIMvx3SyxzkY8aDjNtWKo8FPtLhfzKFAODC6iCpNDXXC0afJStVLHDTd5512hJzMLkBLwYur%2BGNxJNOD7BV9qcdhjJhTsWUOAeZpDA4fUw9bcMrLiraUDkcc0xyieEmv1dvrEvt75Zk%2BoBqEB0d9dQ3DClfAAire1dWwlfkAovCPItwFGDZooKlbZB79SjR4VQbUhRtVxrg%2FXF1Q6kFD3PuwX0pKLWsmHHQGoc4cxW434z6wp9w1RTBByyRXZinhsaF1pHGGv9b3hPj7FYYVXF9b%2B5rBG6XNPJEKy0LWpCc8ndUjp%2BPjyyAS9cTPhDDjqjEcm8ISecF32RsaX7H0a5%2BdPdF7LqvzYa7n6KIZyOPCj0UYyotshiuqgFALzJiNb9oRhzt0OlvscsEfmECHUIDv9zoXED%2FwIlwdkLaFhAc2WcLJhJzGcKz8douXCv7jsfaFW9gZBiKtUd3oYz5wAjUODSofJh5X5os%2FTYz2o3IdblnfYMPFmRJ6kdoeqKzOFHBLstPOFKmdm0KBJKjwcrS0Xzg6NRv%2Fw2L9ynQX3zg%2FKqK5GjRLf0m2gNV2edOlrWWI5Jz0tvPgHPCV8B9fj5m7MEfPqnNn57An6AAYaaEVdPpY3Wgjmoi5O2R%2Bob24LgdgjEw5RjGRCGrxvPNO%2FWxBQ6%2Fh3oC6FSwkS6n4ztsnZrYY9e%2FkMPan%2Btu06ghqxaXDCkZHo49aq%2BkcSmRrewNQw8fQ7EB1V7XbbCvcH0dP2iMVCSIzj4M2ewhz%2FCtV%2BsTKPRgSdQI35o9HAzGSCt3%2F4FYyO8nHr1zZ7PRjomiykyjm5Zv1aPSsXY0mHuQhpgke1JqplBctFXMym7rp2asfTrD3%2B%2FRbzWnj%2BLxin%2FvCuQtAxkCaY88fGj8aiLY9DCi%2BP6sBjqyAXkEIxuI1uqTwYLhp53%2BzJDINunx3Krxuj87xKbptzHLfajhqzeeBES3RpF4Trry6KhDiCed8wBlG8DuS%2BWcn3Ul7jz%2BgaexZeiqRjjjYFE3gmLMHCoWbw0rNE5y2jInuVrjkGpjnzBse0vRFOr122fQu1lVCWJlA14GMQSTxhLhoMimeKHI7H70%2FbiX5xfoeleKNvlVZRz1TSczFaszjH4ZqwvP8PaEml%2Ffs%2FE5pTFDMfI%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240111T104346Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYVQVCC64F%2F20240111%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=c0f31a745a5b5c6c045fc47e8179fa00b3a8cdb85e02e8fd4de9b628b0ddf21e&hash=7fd623da9972744f4324daddab4274e013451aa50b9efd8993cfb811c83adba3&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=0006295267901165&tid=spdf-4901efd3-c3b5-4d30-af70-6cdb0550c59a&sid=452011ed3400b54927291374127bfbc502f4gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=1d045b5b500c58075d5653&rr=843c8f864b27b2f3&cc=gb

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