Compound ID | 2657

Update compound information

Paromamine

Synonym(s): Neomycin D

Class: Aminoglycoside

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus
Description: Natural product from analogues with wider spectrum and improved activity than parent compound reported
Year first mentioned: 1964
Development status: Experimental
Chemical structure(s):
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Molecular weight: 323.34
Iso. SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O)O)N
InChI Key: JGSMDVGTXBPWIM-HKEUSBCWSA-N
Can. SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)N)O)O)N
InChI: InChI=1S/C12H25N3O7/c13-3-1-4(14)11(10(20)7(3)17)22-12-6(15)9(19)8(18)5(2-16)21-12/h3-12,16-20H,1-2,13-15H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/439560
Citations:
  • https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/1439-7633(20021202)3:12%3C1223::AID-CBIC1223%3E3.0.CO;2-W
  • https://pubs.acs.org/doi/10.1021/ja01522a084
  • https://www.jstage.jst.go.jp/article/antibiotics1968/37/1/37_1_77/_pdf/-char/en
  • https://pubs.acs.org/doi/10.1021/jm401148j

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