Altromycin B

Class: DNA minor groove binder

Spectrum of activity:	Gram-negative
Details of activity:	DNA minor grove binder, alkylator
Institute where first reported:	Abbott Laboratories (AbbieVie USA)
Year first mentioned:	1989
Highest developmental phase:	Preclinical
Development status:	Inactive
Reason Dropped:	Probably highly cytotoxic

Chemical structure(s):
Canonical SMILES:	CC1C(C(CC(O1)OC2C(C)OC(CC2(C)N(C)C)C3=CC=C4C(=C3O)C(=O)C5=C(C=C(C6=C5OC(=CC6=O)C7(C)C(C)O7)C(C8C(C(C(C(C)O8)O)OC)O)(C(=O)OC)O)C4=O)OC)O
Isomeric SMILES:	CC1C(C(CC(O1)OC2C(OC(CC2(C)N(C)C)C3=C(C4=C(C=C3)C(=O)C5=CC(=C6C(=O)C=C(OC6=C5C4=O)C7(C(O7)C)C)C(C8C(C(C(C(O8)C)O)OC)O)(C(=O)OC)O)O)C)OC)O
InChI:	InChI=1S/C47H59NO18/c1-18-34(50)27(58-9)16-30(62-18)65-42-20(3)61-28(17-45(42,5)48(7)8)22-12-13-23-31(37(22)53)38(54)32-24(36(23)52)14-25(33-26(49)15-29(64-40(32)33)46(6)21(4)66-46)47(57,44(56)60-11)43-39(55)41(59-10)35(51)19(2)63-43/h12-15,18-21,27-28,30,34-35,39,41-43,50-51,53,55,57H,16-17H2,1-11H3
InChI Key:	FAGGWQMBDCZCOI-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/148125

External links:
Guide to Pharmacology:	Altromycin B