Compound ID | 2668

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Phthiocol

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Streptococcus pyogenes, Streptococcus pneumoniae and at higher concentrations Staphylococcus aureus, Streptococcus salivarius, Corynebacterium diphtheriae, Shigella paradysenteriae and Escherichia coli; Pseudomonas aeruginosa quorum sensing inhibitor
Description: Natural product from Mycobacterium tuberculosis; a naphthoquinone
Year first mentioned: 1946
Development status: Experimental
Chemical structure(s):
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Molecular weight: 188.18
Iso. SMILES: CC1=C(C2=CC=CC=C2C(=O)C1=O)O
InChI Key: BGVCGTNXEKDVCB-UHFFFAOYSA-N
Can. SMILES: CC1=C(C2=C(C=CC=C2)C(=O)C1=O)O
InChI: InChI=1S/C11H8O3/c1-6-9(12)7-4-2-3-5-8(7)11(14)10(6)13/h2-5,12H,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10221
Citations:
  • https://journals.asm.org/doi/10.1128/jb.52.1.145-146.1946
  • https://www.frontiersin.org/articles/10.3389/fmicb.2022.896687/full

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