Compound ID | 2673

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Pleurotin

Synonym(s): Pleurotine

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus
Description: Natural product from basidiomycete Pleurotus griseus; also anti-dermatophyte (Trichophyton mentagrophytes)
Year first mentioned: 1947
Development status: Experimental
Chemical structure(s):
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Molecular weight: 354.4
Iso. SMILES: C[C@H]1CO[C@H]2C3=C([C@H]4[C@H]5[C@@]26CC[C@@H]1[C@H]6CC[C@@H]5C(=O)O4)C(=O)C=CC3=O
InChI Key: QCPDBEXGCHOIDE-ZPUAQPQFSA-N
Can. SMILES: C[C@H]1CO[C@H]2C3=C(C(=O)C=CC3=O)[C@H]4[C@@H]5[C@H](CC[C@@H]6[C@H]1CC[C@]652)C(=O)O4
InChI: InChI=1S/C21H22O5/c1-9-8-25-19-16-14(23)5-4-13(22)15(16)18-17-11(20(24)26-18)2-3-12-10(9)6-7-21(12,17)19/h4-5,9-12,17-19H,2-3,6-8H2,1H3/t9-,10-,11-,12+,17-,18-,19-,21-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/13994131
Citations:
  • https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/62bd9d99e60d987ab0f299c9/original/a-concise-synthesis-of-pleurotin-enabled-by-a-nontraditional-c-h-epimerization.pdf
  • https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0507.2008.01620.x
  • https://www.pnas.org/doi/epdf/10.1073/pnas.33.6.171

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