Compound ID | 2676

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Polymyxin D

Class: Lipopeptide

Spectrum of activity: Gram-negative
Details of activity: Disrupts integrity of cell membrane
Description: Natural product from Bacillus polymyxa
Year first mentioned: 1947
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1144.37
Iso. SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)C(C)O)CCN)CCN)C(C)O
InChI Key: ZVVRUVGEGUZQHF-UHFFFAOYSA-N
Can. SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O
InChI: InChI=1S/C50H93N15O15/c1-8-26(4)11-9-10-12-37(70)56-30(13-18-51)44(74)64-40(29(7)69)50(80)62-36(24-66)47(77)59-34-17-22-55-48(78)38(27(5)67)63-45(75)33(16-21-54)58-41(71)32(15-20-53)60-49(79)39(28(6)68)65-46(76)35(23-25(2)3)61-42(72)31(14-19-52)57-43(34)73/h25-36,38-40,66-69H,8-24,51-54H2,1-7H3,(H,55,78)(H,56,70)(H,57,73)(H,58,71)(H,59,77)(H,60,79)(H,61,72)(H,62,80)(H,63,75)(H,64,74)(H,65,76)
External links:
Citations:
  • https://pharmrev.aspetjournals.org/content/73/2/679
  • https://www.annualreviews.org/doi/10.1146/annurev.bi.46.070177.003451?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
  • https://www.nature.com/articles/ja2016146
  • https://link.springer.com/article/10.1007/BF01901128

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