Compound ID | 2678

Update compound information

Polymyxin M

Synonym(s): Mattacin

Class: Antimicrobial peptide

Agent Type: Natural product; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent. Disrupts integrity of cell membrane
Target Pathogen: Active against Escherichia coli, Klebsiella pneumoniae, Shigella soneii, Pseudomonas putida, Pseudomonas fluorescens, Salmonella enterica serovar Typhimurium, Acinetobacter baumannii, and Vibrio parahaemolyticus
Description: Natural product from Paenibacillus kobensis
Year first mentioned: 2003
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1162.45
Iso. SMILES: CCC(C)CCCCC(=O)N[C@@H](CC[NH3+])C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC[NH3+])C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC[NH3+])CC(C)C)C(C)O)CC[NH3+])CC[NH3+])C(C)O
InChI Key: XRBFWBMDMQIAQF-IRLGFUFXSA-S
Can. SMILES: CCC(C)CCCCC(=O)N[C@@H](CC[NH3+])C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC[NH3+])C(=O)N[C@H]1CCNC(=O)[C@H](C(C)O)NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](C(C)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC[NH3+])NC1=O
InChI: InChI=1S/C51H96N16O14/c1-8-27(4)11-9-10-12-38(71)58-31(13-19-52)46(76)66-40(29(6)69)50(80)63-34(16-22-55)43(73)61-36-18-24-57-49(79)39(28(5)68)65-47(77)35(17-23-56)60-42(72)33(15-21-54)62-51(81)41(30(7)70)67-48(78)37(25-26(2)3)64-44(74)32(14-20-53)59-45(36)75/h26-37,39-41,68-70H,8-25,52-56H2,1-7H3,(H,57,79)(H,58,71)(H,59,75)(H,60,72)(H,61,73)(H,62,81)(H,63,80)(H,64,74)(H,65,77)(H,66,76)(H,67,78)/p+5/t27?,28?,29?,30?,31-,32-,33-,34-,35-,36-,37+,39-,40-,41-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/90659172
Citation: https://www.sciencedirect.com/science/article/pii/S0021925819646909?via%3Dihub

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