Compound ID | 2683

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Polyporin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Unknown
Target Pathogen: Active against Salmonella Typhi, Escherichia coli, Vibrio cholerae, Streptococcus pyogenes, Streptococcus viridans and Staphylococcus aureus
Description: Natural product from Polystictus sanguineus (also by Polyporus sp.); non-haemolytic and no pyrogenic effect to human when administered via intramuscular injection in human; clinical trials in Calcutta hospitals (1944-1946) of the crude extract had been reported
Institute where first reported: Indian Health Institute and Laboratories Ltd. (Beliaghata Calcutta)
Year first mentioned: 1944
Development status: Experimental
Chemical structure(s):
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Molecular weight: 292.29
Iso. SMILES: O=C1C(O)=C(C(=O)C(O)=C1C2=CC=CC=C2)C3=CC=CC=C3
InChI Key: HZKFHDXTSAYOSN-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)C2=C(C(=O)C(=C(C2=O)O)C3=CC=CC=C3)O
InChI: InChI=1S/C18H12O4/c19-15-13(11-7-3-1-4-8-11)16(20)18(22)14(17(15)21)12-9-5-2-6-10-12/h1-10,19,22H
External links:
Citations:
  • https://www.jstor.org/stable/4353461?saml_data=eyJzYW1sVG9rZW4iOiJjYzljMjNkNS1lNmY1LTRjN2ItYjY4Zi1kMTVlYmM2ZDlmMzEiLCJlbWFpbCI6IkwuSC5HYWxhcmlvbkBsZWVkcy5hYy51ayIsImluc3RpdHV0aW9uSWRzIjpbImI5M2UwZWMwLTAwOTMtNGVmYy1iMzhlLTA4NmZiZGY1YTVkOCJdfQ&seq=48
  • https://www.nature.com/articles/158292a0
  • https://www.nature.com/articles/156171a0

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