Compound ID | 2686

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Prasinomycin

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Lactobacillus casei, Mycobacterium bovis, and Mycobacterium fortuitum
Propensity to select resistant mutants: Develops rapidly (in vitro assay with Staphylococcus aureus)
Description: Natural product from Streptomyces prasinus; only effective against growing cells; active only against growing cells; protects mice from Streptococcus infection only when administered subcutaneously and not orally; shows prophylactic action (vs. Staphylococcus infection in mice)
Institute where first reported: Squibb Institute for Medical Research, New Brunswick, New Jersey 08903 USA
Year first mentioned: 1968
Development status: Experimental
External links:
Citations:
  • https://onlinelibrary.wiley.com/doi/abs/10.1002/bit.260130307
  • https://www.nature.com/articles/2131092a0
  • https://journals.asm.org/doi/10.1128/am.16.4.603-608.1968?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
    • Patent: US3493653A

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