Compound ID | 2688

Update compound information

Proactinomycin

Class: Natural product antibiotic

Agent Type: Natural product;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, and Neisseria (not active against other Gram-negatives tested)
Description: Natural product from Nocardia (Proactinomyces) gardneri; analogues with activity reported
Year first mentioned: 1949
Development status: Experimental
External links:
Citations:
  • https://pdf.sciencedirectassets.com/271074/1-s2.0-S0140673600X70353/1-s2.0-S0140673646914304/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjENb%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQDTLM4%2BmBI%2B%2Box4ses3TYsQGxHSlWoQ%2FHZfhxWBPmKzPwIgV5dgA9GMtP5THIBze6HOmJv6d8eiySaQnHEevASHfZIquwUIj%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAFGgwwNTkwMDM1NDY4NjUiDPhT%2BpXTKIg7FJCgfCqPBdzL4O3UBjzfFybZx9zewFuSjJUZ2brovuEjYOUwxCe75H%2FTYJE4vCcYlJvR%2BrRa3cExpG9w%2FP8LN5ExoP5QzLdAMaJcMuh2diNsNr32QWmVYs4wSgy1%2FQRVTzFCTiFpbU8WBvUyvCishds4oQVetH%2F1fX%2Bn7Vo4gL3xf2Tc7d0j8lQs0svv4uOte0uoV0DeHg7la%2F1%2BIDeFX62ImWanfP%2FZoqaBjqLCeOw6lO6SyLWEDXATkvzldyZlRyPyj%2FH4doQCuR0BcK9ndp4BVvMjuU50RTKTmZZESo3nyMfPaSFpWA726OrxBMyUWezkA5ox8I3SeahqkbSviNu0%2BxNvt1BFyk1ZAMqo%2FEKOXJySeSpyTKF3PoCX%2F6Qloz4%2Fr9iANPsvW8qoJP1WJgG04KLnNIcXbZbk6nQSLgJ2O5%2FFqBh1B79UrGcEmPf4%2F2C1hBo7mkAtgH1KCBDMkgkCd0rgFZ%2FOMQ4x7StGgjbuTdhFwRrIJ3VMbE0lIo9TcXaRmV8gZ6rWffqifA1xbpathhImARPHWYKn93Ph7XJuiEm%2BhPonDh2mOe%2Fq3R4vgiPPFHr8FNpmAASSwdQJcZPrPHfnmlylmH4jOUySG1wEMIuXDpInTZlPT%2Fu5Xm%2FGMObc3FjYRXgqbYSjlx1E4afldez4q2NuunAEKALYAs%2Bs90Li8BNM%2FQnLWfCAmv61jq17nwCwT34%2BJ%2FjvDV9wNwUltyH3b2nYXMwprcjtHq%2BF6ywD3A6rvkpEKOj6EMLL5LQrBCKu0MqSrl9zjINFBk56jZ61gbFRg3zWfZGj76w7ToN97ZZK5CeaVDtuFxORwojERLl33DQZ%2FuOFg%2B12r4t9PTFdq%2FASgKaKkhS95rkAjKGjP3owvdTJrQY6sQEKD4Fm6XSYZa%2B4DUnSFVyAWnao29xSzKVBQWo9qf5UbjGVXzP27VjT1S5zKfd7qWhMhbwiznnicD5znA33tQAWldZfl8FHmHDGMdhUjpTMmJr61DmcaZfOJD7ahb%2Fyi%2FYP3yDNLPkNTmTVvO04rEvn1btzFLQUEFONV6pphSpEFe3ZRPkNU3W%2Bt9OLnFYQ7oOOxKbRL1ogwcqisrFuocQ7sNdH7D4ZAle4VHsoGTeqfb4%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240125T143708Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYYZ2ZYVF6%2F20240125%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=6e1725aafb59c17ad3289e8459018b66e340f7f3622f66eeedb1d818fb4d04f9&hash=4c059ed8dab2249438202da847b06ba04672b1916b775164d85fc786910d8558&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0140673646914304&tid=spdf-7b703f71-a446-4c39-bc3f-1b38fa20c4bc&sid=70cb8d6d73ddc942985b2a5373442b66fa1cgxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=1d045b5b015e54515c0202&rr=84b1409bed52075e&cc=gb
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2073294/pdf/brjexppathol00071-0044.pdf
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065499/pdf/brjexppathol00177-0022.pdf

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