Compound ID | 2695

Update compound information

Puromycin

Synonym(s): Aachromycin

Class: Aminoglycoside

Spectrum of activity: Gram-positive
Details of activity: Targets protein synthesis
Description: Natural product from Streptomyces alboniger; an aminoacyl nucleoside antibiotic (structurally similar to aa-tRNA)
Year first mentioned: 1979
Development status: Experimental
Chemical structure(s):
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Molecular weight: 471.51
Iso. SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
InChI Key: RXWNCPJZOCPEPQ-NVWDDTSBSA-N
Can. SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
InChI: InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/439530
Guide to Pharmacology: puromycin
Citations:
  • https://journals.asm.org/doi/abs/10.1128/aac.8.6.721
  • https://www.sciencedirect.com/science/article/pii/S0021925817449672?via%3Dihub
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229235/

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