Puromycin

Synonym(s): Aachromycin

Class: Aminoglycoside

Spectrum of activity:	Gram-positive
Details of activity:	Targets protein synthesis
Description:	Natural product from Streptomyces alboniger; an aminoacyl nucleoside antibiotic (structurally similar to aa-tRNA)
Year first mentioned:	1979
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
Isomeric SMILES:	CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
InChI:	InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1
InChI Key:	RXWNCPJZOCPEPQ-NVWDDTSBSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/439530

External links:
Guide to Pharmacology:	puromycin
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229235/
Citations:	https://journals.asm.org/doi/abs/10.1128/aac.8.6.721 https://www.sciencedirect.com/science/article/pii/S0021925817449672?via%3Dihub