Compound ID | 2701

Update compound information

Azalomycin F

Class: Macrolide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus; disrupts integrity of cell membrane
Description: Natural product from Streptomyces hygroscopicus
Year first mentioned: 1995
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1068.34
Iso. SMILES: CC1CCC(C(C(CC(C(/C=C/C=C(/C(=O)OC(C(/C=C/C=C(/C(CC(CC(CC(CC2CC(C(C(O2)(CC1O)O)O)O)OC(=O)CC(=O)O)O)O)O)\C)C)C(C)CCC/C=C/CCCN=C(N)N)\C)C)O)O)C)O
InChI Key: UVUPYXTUQSCQRV-PEKXHOPKSA-N
Can. SMILES: C/C/1=C\C=C\C(C)C(C(C)CCC/C=C/CCCN=C(N)N)OC(=O)/C(=C/C=C/C(C)C(CC(C(C)C(CCC(C)C(CC2(C(C(CC(CC(CC(CC(CC1O)O)O)OC(=O)CC(=O)O)O2)O)O)O)O)O)O)O)/C
InChI: InChI=1S/C55H93N3O17/c1-32-17-14-19-36(5)51(35(4)16-12-10-8-9-11-13-23-58-54(56)57)74-53(71)37(6)20-15-18-33(2)45(63)29-46(64)38(7)43(61)22-21-34(3)48(66)31-55(72)52(70)47(65)28-42(75-55)27-41(73-50(69)30-49(67)68)25-39(59)24-40(60)26-44(32)62/h8-9,14-15,17-20,33-36,38-48,51-52,59-66,70,72H,10-13,16,21-31H2,1-7H3,(H,67,68)(H4,56,57,58)/b9-8+,18-15+,19-14+,32-17+,37-20+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6450216
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588360/
  • https://www.sciencedirect.com/science/article/pii/S075333221835978X#:~:text=Azalomycin%20F5a%20disrupts%20the%20cell%20membrane%20by%20interacting%20with%20phospholipid.
  • https://www.jstage.jst.go.jp/article/antibiotics1968/48/8/48_8_896/_article

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