Compound ID | 2703

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Salivabactin

Class: Antimicrobial peptide

Agent Type: Natural product;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Streptococcus pyogenes including Streptococcus pneumoniae, Streptococcus mutans, and Staphylococcus aureus
Description: Engineered natural product from the oral probiotic Streptococcus salivarius K12; in vivo potency comparable to penicillin G in mice Group A streptococci infection; lantibiotic-type
Institute where first reported: Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, TX, USA
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
Salivabactin A
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Molecular weight: 273.35
Iso. SMILES: OC1=CC=C(C(/C=C\2/NC(/C=C/C=C)CS2)=O)C=C1
InChI Key: WNVNCEYXPGYHEH-FGCJIXDNSA-N
Can. SMILES: C=C/C=C/C1CS/C(=C\C(=O)C2=CC=C(C=C2)O)/N1
InChI: InChI=1S/C15H15NO2S/c1-2-3-4-12-10-19-15(16-12)9-14(18)11-5-7-13(17)8-6-11/h2-9,12,16-17H,1,10H2/b4-3+,15-9-
Salivabactin B
Click here for structure editor
Molecular weight: 273.35
Iso. SMILES: OC1=CC=C(C(/C=C/2\NC(/C=C/C=C)CS2)=O)C=C1
InChI Key: WNVNCEYXPGYHEH-BJIYECEJSA-N
Can. SMILES: C=C/C=C/C1CS/C(=C/C(=O)C2=CC=C(C=C2)O)/N1
InChI: InChI=1S/C15H15NO2S/c1-2-3-4-12-10-19-15(16-12)9-14(18)11-5-7-13(17)8-6-11/h2-9,12,16-17H,1,10H2/b4-3+,15-9+
External links:
Citation: https://www.nature.com/articles/s41564-023-01583-9

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