Compound ID | 2726

Update compound information

Salinomycin

Class: Natural product antibiotic (polyether antibiotic, ionophore)

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Facilitates transport of cations through cell membrane
Target Pathogen: Active against Staphylococcus aureus, Staphylococcus epidermidis, Mycobacterium smegmatis, Mycobacterium phlei, and Mycobacterium avium
Description: Natural product from Streptomyces albus; anticoccidial and anti-tumour properties
Institute where first reported: Research Division. Kaken Chemical Co., Ltd.. Kita-ku, Tokyo, Japan
Year first mentioned: 1974
Development status: Experimental
Chemical structure(s):
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Molecular weight: 751
Iso. SMILES: CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O
InChI Key: KQXDHUJYNAXLNZ-XQSDOZFQSA-N
Can. SMILES: CC[C@H]([C@H]1CC[C@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@@H](C)C[C@@H](C)[C@@]3(C=C[C@H]([C@]4(CC[C@@](C)([C@H]5CC[C@](CC)([C@H](C)O5)O)O4)O3)O)O2)O)O1)C(=O)O
InChI: InChI=1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3085092
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/27/11/27_11_814/_pdf/-char/en
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102832/#:~:text=The%20molecular%20formula%20of%20salinomycin,protozoa%20and%20gram%2Dpositive%20bacteria.

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