Compound ID | 275

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RP60556A

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus sp., Streptococcus sp., and Enterococcus sp.
Description: Synthetic compound with benzo[b]naphthyridone scaffold; formulated as 2% active compound for topical application; shows efficacy towards Staphylococcus aureus cutaneous infection in guinea-pig model
Institute where first reported: Aventis (Sanofi-Aventis, France)
Year first mentioned: 2000
Development status: Experimental
Chemical structure(s):
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Molecular weight: 450.44
Iso. SMILES: CN1C=C(C(=O)C2=C1N=C3C=C(C(=CC3=C2)F)N4CCN(CC4)C5=CC=C(C=C5)F)C(=O)O
InChI Key: YYHFVZLNDMSUBV-UHFFFAOYSA-N
Can. SMILES: CN1C=C(C(=O)C2=CC3=C(C=C(C(=C3)F)N4CCN(CC4)C5=CC=C(C=C5)F)N=C21)C(=O)O
InChI: InChI=1S/C24H20F2N4O3/c1-28-13-18(24(32)33)22(31)17-10-14-11-19(26)21(12-20(14)27-23(17)28)30-8-6-29(7-9-30)16-4-2-15(25)3-5-16/h2-5,10-13H,6-9H2,1H3,(H,32,33)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/484065
Guide to Pharmacology: RP60556A
Citation: https://www.sciencedirect.com/science/article/pii/S0960894X01000919?via%3Dihub

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