Compound ID | 2761

Update compound information

Tenebrimycin

Synonym(s): Nebramycin  |  Tenemycin

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella sp., Proteus sp., Salmonella typhimurium, Salmonella typhosa, and Shigella flexneri; protein synthesis inhibitor
Description: Natural product from Streptomyces tenebrarius
Institute where first reported: Eli Lilly and Company, Indianapolis, Ind. USA
Year first mentioned: 1972
Development status: Experimental
Chemical structure(s):
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Molecular weight: 467.52
Iso. SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N
InChI Key: NLVFBUXFDBBNBW-UHFFFAOYSA-N
Can. SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(CO)O2)O)N)O)O)OC3C(CC(C(CN)O3)O)N)N
InChI: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5496
Citations:
  • https://patents.google.com/patent/US3691279A/en
  • https://patentimages.storage.googleapis.com/c6/7e/1e/cd915212a5dc9b/US3691279.pdf

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