Compound ID | 2778

Update compound information

Variapeptin

Class: Antimicrobial peptide

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus
Description: Natural product from Streptomyces variabilis; shows anti-tumour activity; a hexadepsipeptide
Institute where first reported: Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., 3 Miyahara, Takasaki-shi, Gunma 370-12, Japan
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight: 945.11
Iso. SMILES: CCC(C)CC1CCC(OC1C)(C(C)(C(=O)NC2C(OC(=O)C(NC(=O)C3CCCNN3C(=O)C(N(C(=O)C(N(C(=O)C4CCCNN4C2=O)O)C)C)CC5=CC=CC=C5)CO)C(C)C)O)O
InChI Key: PBXKWAYVRNEWSB-UHFFFAOYSA-N
Can. SMILES: CCC(C)CC1CCC(C(C)(C(=O)NC2C(C(C)C)OC(=O)C(CO)NC(=O)C3CCCNN3C(=O)C(CC4=CC=CC=C4)N(C)C(=O)C(C)N(C(=O)C5CCCNN5C2=O)O)O)(O)OC1C
InChI: InChI=1S/C46H72N8O13/c1-9-27(4)23-31-19-20-46(64,67-29(31)6)45(7,63)44(62)50-36-37(26(2)3)66-43(61)32(25-55)49-38(56)33-17-13-21-47-52(33)40(58)35(24-30-15-11-10-12-16-30)51(8)39(57)28(5)54(65)41(59)34-18-14-22-48-53(34)42(36)60/h10-12,15-16,26-29,31-37,47-48,55,63-65H,9,13-14,17-25H2,1-8H3,(H,49,56)(H,50,62)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3081754
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/43/5/43_5_477/_pdf/-char/en
  • https://www.jstage.jst.go.jp/article/bbb1961/54/3/54_3_791/_pdf/-char/en

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