Compound ID | 278

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MBX1162

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Likely DNA minor groove binder
Target Pathogen: Broad spectrum activity
Institute where first reported: Microbiotix Inc. USA
Year first mentioned: 2009
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 472.58
Iso. SMILES: C1CNC(=NC1)C2=CC3=C(C=C2)C=C(N3)C4=CC=C(C=C4)C5=CC6=C(N5)C=C(C=C6)C7=NCCCN7
InChI Key: CYZKZDNPVSMEPI-UHFFFAOYSA-N
Can. SMILES: C1CNC(=NC1)C2=CC3=C(C=C2)C=C(C4=CC=C(C=C4)C5=CC6=C(C=C(C=C6)C7=NCCCN7)N5)N3
InChI: InChI=1S/C30H28N6/c1-11-31-29(32-12-1)23-9-7-21-15-25(35-27(21)17-23)19-3-5-20(6-4-19)26-16-22-8-10-24(18-28(22)36-26)30-33-13-2-14-34-30/h3-10,15-18,35-36H,1-2,11-14H2,(H,31,32)(H,33,34)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25022473
Citation: https://aac.asm.org/content/aac/54/9/3974.full.pdf

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