Compound ID | 2780

Update compound information

Viridogrisein

Synonym(s): Etamycin

Class: Streptogramin

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Corynebacterium diphtheriae, Diplococcus pneumoniae, Streptococcus agalactiae, Streptococcus pyogenes, and Mycobacterium abscessus
Description: Natural product from Streptomyces griseoviridis (also by Streptomyces griseus); analogues reported from Streptomyces niveoruber
Institute where first reported: Parke, Davis & Company, Detroit, Michigan USA
Year first mentioned: 1958
Development status: Experimental
Chemical structure(s):
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Molecular weight: 879.01
Iso. SMILES: CC1C(C(=O)NC(C(=O)N2CC(CC2C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)O1)C3=CC=CC=C3)C)C)C(C)C(C)C)C)C)O)CC(C)C)NC(=O)C4=C(C=CC=N4)O
InChI Key: SATIISJKSAELDC-UHFFFAOYSA-N
Can. SMILES: CC(C)CC1C(=O)N2CC(CC2C(=O)N(C)CC(=O)N(C)C(C(C)C(C)C)C(=O)NC(C)C(=O)N(C)C(C3=CC=CC=C3)C(=O)OC(C)C(C(=O)N1)NC(=O)C4=NC=CC=C4O)O
InChI: InChI=1S/C44H62N8O11/c1-23(2)19-30-42(60)52-21-29(53)20-31(52)43(61)49(8)22-33(55)50(9)36(25(5)24(3)4)40(58)46-26(6)41(59)51(10)37(28-15-12-11-13-16-28)44(62)63-27(7)34(38(56)47-30)48-39(57)35-32(54)17-14-18-45-35/h11-18,23-27,29-31,34,36-37,53-54H,19-22H2,1-10H3,(H,46,58)(H,47,56)(H,48,57)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/417256
Citations:
  • https://patentimages.storage.googleapis.com/c0/15/f8/f54d23ea983acd/US3023204.pdf
  • https://pubs.rsc.org/en/content/articlepdf/1958/jr/jr9580004466
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555287/#:~:text=The%20mechanism%20of%20action%20of,activity%20in%20all%20three%20models.
  • https://www.jstage.jst.go.jp/article/cpb/72/1/72_c23-00776/_html/-char/ja

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