Compound ID | 2787
VanQAmC10
Class: Glycopeptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Cell wall synthesis inhibitor |
| Target Pathogen: | Broad-spectrum activity inlcuding methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and -resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus ; strong activity towards carbapenem-resistant Acinetobacter baumannii including biofilms |
| Description: | Semisynthetic derivative of vancomycin that has broad-spectrum activity; half maximal haemolytic concentration = 1000 uM vs MIC at 3.9-15.5 uM |
| Institute where first reported: | Antimicrobials Research Laboratory, New Chemistry Unit and School of Advanced Materials, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, Karnataka, India |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acschembio.0c00091 |
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