Compound ID | 279

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MBX1090

Class: Bis-indole

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Anti-tubercular (MDR TB (MIC ≤ 0.02-1.25 µg/mL) compounds synthesised by Microbiotix, the company seems to have moved onto research of spectinamides for MDR TB treatment
Institute where first reported: Microbiotix Inc. USA
Year first mentioned: 2009
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 394.47
Iso. SMILES: C1CN=C(N1)C2=CC3=C(C=C2)C=C(N3)/C=C/C4=CC5=C(N4)C=C(C=C5)C6=NCCN6
InChI Key: IOVATJAOKLNFKP-AATRIKPKSA-N
Can. SMILES: C1=CC(=CC2=C1C=C(/C=C/C3=CC4=C(C=C(C=C4)C5=NCCN5)N3)N2)C6=NCCN6
InChI: InChI=1S/C24H22N6/c1-3-17(23-25-7-8-26-23)13-21-15(1)11-19(29-21)5-6-20-12-16-2-4-18(14-22(16)30-20)24-27-9-10-28-24/h1-6,11-14,29-30H,7-10H2,(H,25,26)(H,27,28)/b6-5+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5478796
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764145/pdf/1709-08.pdf
  • http://www.microbiotix.com/posters/ICACC-2009/ICAAC%202009%20Butler%2009-04-09.pdf
  • https://aac.asm.org/content/aac/54/9/3974.full.pdf

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