Compound ID | 2792

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Amycobactin

Class: Natural product antibiotic

Details of activity: Active against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium abscessus, and Mycobacterium paratuberculosis; inhibits protein secretion via Sec translocation (SecY inhibitor)
Description: Natural product from Amycolatopsis sp. discovered form screening fermentation broths of previously uncultured bacteria; shows 50% cytotoxicity to liver and mouse embryonic fibroblast cell lines at 16-32 ug/ml
Institute where first reported: Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA; NovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 762.92
Iso. SMILES: CC(CC(C)C(C1=CC(O)=C(C)C(O)=C1)=O)C2CCCCC(C)C(OC(C)=O)C(OC)C3C(O)CCC4(O3)C(C)C(C(C)C(O4)C(C)C(O)CC(O2)=O)=O
InChI Key: DONRWJMNVLPBGL-UHFFFAOYSA-N
Can. SMILES: CC1CCCCC(C(C)CC(C)C(=O)C2=CC(=C(C)C(=C2)O)O)OC(=O)CC(C(C)C3C(C)C(=O)C(C)C4(CCC(C(C(C1OC(=O)C)OC)O4)O)O3)O
InChI: InChI=1S/C41H62O13/c1-20-12-10-11-13-33(21(2)16-22(3)35(48)28-17-30(44)23(4)31(45)18-28)52-34(47)19-32(46)24(5)38-25(6)36(49)26(7)41(53-38)15-14-29(43)39(54-41)40(50-9)37(20)51-27(8)42/h17-18,20-22,24-26,29,32-33,37-40,43-46H,10-16,19H2,1-9H3
External links:
Citation: https://pubmed.ncbi.nlm.nih.gov/32753498/

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