Compound ID | 2793
Kitamycobactin
Class: Natural product antibiotic
| Agent Type: | Natural product; Direct acting; Antivirulence; |
| Spectrum of activity: | Antimycobacterial |
| Mechanism of action: | ClpP1P2C1 inhibitor |
| Target Pathogen: | Active against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium abscessus, and Mycobacterium paratuberculosis |
| Description: | Natural product from Kitasatospora sp. discovered from screening fermentation broths of previously uncultured bacteria; lasso peptide; shows no cytotoxicity towards liver cell line and mouse embryonic fibroblast cell line (highest concentration tested: 100 ug/ml) |
| Institute where first reported: | Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA; NovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubmed.ncbi.nlm.nih.gov/32753498/ |
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