Compound ID | 2798
Hypochlorous acid producing electrochemical bandage (HOCl e-bandage)
Class: DNA synthesis inhibitor
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | DNA synthesis inhibitor. Additionally isrupts ATP production and oxidizes thiol-containing proteins |
| Target Pathogen: | Active against Pseudomonas aeruginosa, Escherichia coli, methicillin-resistant and -susceptible Staphylococcus aureus, Staphylococcus epidermidis, Corynebacterium amycolatum, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Klebsiella pneumoniae, Streptococcus pyogenes, Enterobacter aerogenes, and vancomycin-resistant Enterococcus faecium |
| Description: | Electrochemical bandage delivering low-levels of hypochlorous acid; shows 2.2 log CFU/ml reduction of Pseudomonas aeruginosa dermal wound infection in mouse; reduces purulence supporting wound healing; active molecule does not persist when in solution (requires a sustained delivery system) |
| Institute where first reported: | Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA |
| Year first mentioned: | 2007 |
| Development status: | Experimental |
| External links: | |
| Citations: |
|
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.