Compound ID | 280

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MBX1113

Class: Bis-indole

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Anti-tubercular (MDR TB (MIC ≤ 0.02-1.25 µg/mL) compounds synthesised by Microbiotix, the company seems to have moved onto research of spectinamides for MDR TB treatment
Institute where first reported: Microbiotix Inc. USA
Year first mentioned: 2009
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 368.44
Iso. SMILES: C1CN=C(N1)C2=CC3=C(C=C2)C=C(N3)C4=CC5=C(C=C4)C=C(N5)C6=NCCN6
InChI Key: CIMYQJMWLWDPJV-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1C3=CC4=C(C=C(C=C4)C5=NCCN5)N3)NC(=C2)C6=NCCN6
InChI: InChI=1S/C22H20N6/c1-2-15-11-20(22-25-7-8-26-22)28-18(15)10-13(1)17-9-14-3-4-16(12-19(14)27-17)21-23-5-6-24-21/h1-4,9-12,27-28H,5-8H2,(H,23,24)(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/439143
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764145/pdf/1709-08.pdf
  • http://www.microbiotix.com/posters/ICACC-2009/ICAAC%202009%20Butler%2009-04-09.pdf
  • https://aac.asm.org/content/aac/54/9/3974.full.pdf

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