Compound ID | 280

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MBX1113

Class: Small molecule antibacterial agent

Agent Type: Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: DNA synthesis inhibitor. Likely DNA minor groove binder
Target Pathogen: Active against resistant strains of Bacillus anthracis and Staphylococcus aureus, and Mycobacterium smegmatis
Institute where first reported: Microbiotix Inc. USA
Year first mentioned: 2009
Development status: Experimental
Chemical structure(s):
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Molecular weight: 368.44
Iso. SMILES: C1CN=C(N1)C2=CC3=C(C=C2)C=C(N3)C4=CC5=C(C=C4)C=C(N5)C6=NCCN6
InChI Key: CIMYQJMWLWDPJV-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1C3=CC4=C(C=C(C=C4)C5=NCCN5)N3)NC(=C2)C6=NCCN6
InChI: InChI=1S/C22H20N6/c1-2-15-11-20(22-25-7-8-26-22)28-18(15)10-13(1)17-9-14-3-4-16(12-19(14)27-17)21-23-5-6-24-21/h1-4,9-12,27-28H,5-8H2,(H,23,24)(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/439143
Citation: https://journals.asm.org/doi/10.1128/aac.01709-08

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