Compound ID | 2802

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Maleimide-diselenide hybrid compound (YH7), YH7

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against methicillin-resistant and susceptible Staphylococcus aureus (planktonic and biofilm)
Description: Synthetic compound; mammalian cytotoxicity (IC50) at 128 ug/ml vs MIC at 16 ug/ml; inhibits biofilm formation of methicillin-resistant and -susceptible Staphylococcus aureus in SarX-dependent manner
Institute where first reported: Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 497.31
Iso. SMILES: O=C1C([Se]C2=CC=CC=C2)=C([Se]C3=CC=CC=C3)C(N1CC4=CC=CC=C4)=O
InChI Key: SKYWWMWKMFOALL-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)CN2C(=O)C(=C(C2=O)[Se]C3=CC=CC=C3)[Se]C4=CC=CC=C4
InChI: InChI=1S/C23H17NO2Se2/c25-22-20(27-18-12-6-2-7-13-18)21(28-19-14-8-3-9-15-19)23(26)24(22)16-17-10-4-1-5-11-17/h1-15H,16H2
External links:
Citation: https://journals.asm.org/doi/10.1128/msphere.00564-23

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