Compound ID | 2805

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Compound IV (4-[(4-methoxyphenyl)methylsulfanyl]−7-nitro-2,1,3-benzoxadiazole)

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Helicobacter pylori
Description: Synthetic compound; combination at 4x MIC of compound IV with amoxicillin, metronidazole, levofloxacin, or rifampicin prevents regrowth of Helicobacter pyrlori
Institute where first reported: INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 317.32
Iso. SMILES: COC1=CC=C(C=C1)CSC2=CC=C(C3=NON=C23)[N+](=O)[O-]
InChI Key: KIUBYIRTUBYMAX-UHFFFAOYSA-N
Can. SMILES: COC1=CC=C(C=C1)CSC2=CC=C(C3=NON=C23)[N+](=O)[O-]
InChI: InChI=1S/C14H11N3O4S/c1-20-10-4-2-9(3-5-10)8-22-12-7-6-11(17(18)19)13-14(12)16-21-15-13/h2-7H,8H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2821622
Citation: https://journals.asm.org/doi/10.1128/spectrum.02623-23

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