Compound ID | 2806

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Fisetin

Class: Antivirulence agent

Agent Type: Natural product; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: Targets T3SS-1; inhibits Salmonella invasion
Target Pathogen: Active against Salmonella enterica
Description: Natural product from plants (flavonoid); undergoes rapid metabolism, enzymatic degradation, and efflux in gastrointestinal tract of animal models when administered orally
Institute where first reported: State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Center for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun, Jilin, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 286.24
Iso. SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O
InChI Key: XHEFDIBZLJXQHF-UHFFFAOYSA-N
Can. SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=CC=C(C=C3O2)O)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5281614
Citation: https://journals.asm.org/doi/10.1128/spectrum.02406-23

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