Compound ID | 281

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MBX1128

Class: Bis-indole

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Anti-tubercular (MDR TB (MIC ≤ 0.02-1.25 µg/mL) compounds synthesised by Microbiotix, the company seems to have moved onto research of spectinamides for MDR TB treatment
Institute where first reported: Microbiotix Inc. USA
Year first mentioned: 2009
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 484.55
Iso. SMILES: C1CN=C(N1)C2=CC3=C(C=C2)C=C(N3)C4=CC5=C(C=C4)C=C(N5)C6=CC7=C(C=C6)OC(=C7)C8=NCCN8
InChI Key: UHBFGIHBGNHLAX-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC2=C1C=C(C3=CC4=C(C=C3)OC(=C4)C5=NCCN5)N2)C6=CC7=C(C=C(C=C7)C8=NCCN8)N6
InChI: InChI=1S/C30H24N6O/c1-2-19(25-14-20-3-4-21(15-26(20)36-25)29-31-7-8-32-29)13-24-18(1)12-23(35-24)17-5-6-27-22(11-17)16-28(37-27)30-33-9-10-34-30/h1-6,11-16,35-36H,7-10H2,(H,31,32)(H,33,34)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/435425
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764145/pdf/1709-08.pdf
  • http://www.microbiotix.com/posters/ICACC-2009/ICAAC%202009%20Butler%2009-04-09.pdf
  • https://aac.asm.org/content/aac/54/9/3974.full.pdf

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